ABSTRACT
Phosphoinositide-3 kinase (PI3K)/protein kinase B (PKB/AKT)/mammalian target of rapamycin (mTOR) pathway is associated with cell proliferation, survival and migration. It plays an important role in the process of tumorgenesis. As a kind of antitumor target, numerous researches have focused on this pathway in recent years. This review summarizes the advances in regulation, protein expression and targeted therapy of PI3K-AKT/mTOR pathway for gastric cancer, and predicts the hot spots of this pathway in gastric cancer in the future studies. Copyright © 2014 by TUMOR.
ABSTRACT
Objective: This study aimed to determine the relationships between serum levels of vascular endothelial growth factor (VGEF), interleukin-6 (IL-6), basic fibroblast growth factor (bFGF), β2 -microglobin (β2-MG) and the parameters of International Prognostic Index (IPI) in patients with diffuse large B cell lymphoma (DLBCL). Methods: Thirty three newly diagnosed DLBCL patients were divided into two groups: low risk group (IPI <2) and moderate to high risk group (IPI≥2). Serum levels of VEGF, IL-6, and bFGF were measured by enzyme-linked immunosorbent assay. Radioimmunoassay was applied to detect the serum level of β2-MG. Results: Serum levels of β2-MG, VEGF, bFGF, and IL-6 were significantly elevated in the high risk group than those in the low risk group. Conclusions: The serum levels of β2-MG, VEGF, bFGF, and IL-6 combined with IPI can be used for evaluating the prognosis of DLBCL patients. Detection of these cytokines provides the clue for implementing appropriate therapeutic approaches for individual patients and designing new clinical trails.